It is pretty much plug n play if you are just wanting to use a different controller. Most are supported so any combination you can think of works very simply by plugging in the Cronus, attaching the correct controller to validate, then unplugging it and plugging in the one from any other system you want to use. For some switches you have to use a computer program (included) to map button functionality over to the new controller.
It doesnt end there as with the program you can remap buttons any way you want as well as employ a host of mods without phyically changing the controller. Rapid fire, turbo, axis deadening, etc. Pretty much anything.
I dont know anything about Bluetooth support as i havent tried that function.